Medication Choice in Parkinson's Disease

Parkinson's disease (PD) is a neurological pathologic condition with the prevalence about 1 of every 100 individuals older than 55 years old in US alone. Main manifestations are commonly come from motoric system: resting tremor, rigidity of movement, bradykinesia, and postural instability (causes gait abnormality). Pathology of this disease is due to loss of dopaminergic neurons of the substansia nigra of the brain. This loss of dopaminergic neurons cause emergence of neurologic deficits which depend on dopaminergic system. Relatively, acetylcholine/dopamine ratio will rise and this cause more profound of tremor in patients.